Although the disease is characterized by Virus
Proof Protocol Review increased IgE, the immune system is highly comprised by white blood cell abnormalities and cytokines (a type of signaling proteins). The disease is a rare one usually characterized with increased staphylococcal infections mainly on the skin, lungs, forehead and bones. Bacterial agents that cause or trigger Job Syndrome are the S. pneumoniae, H. influenzae, C. albicans and the herpes virus. The common symptoms include, skin rashes and eczema, pus from the sinus and/or bone and dental deformities.
Although not much is known about this disease, recently one of the genes responsible has been identified as STAT3. It is thought that mutations in the STAT3 gene cause Job syndrome. It is an autosomal dominant disorder meaning just one copy of an altered gene in each cell is ample to cause the disorder. STAT3 is a cell signaling molecule responsible for cell functions such as cell growth and division, cell movement, extracelluar matrix formation (such as bones) and apoptosis (self destruction of redundant/defective cells). Mutations or variations in the genes coding for the STAT3 gene are also responsible for diseases such as Crohn's disease and ulcerative colitis both inflammatory bowel diseases.
Unfortunately as not much is known about the disorder, its treatment and prognosis is not fully known, understood or documented. However known cases have been treated with antibiotics to treat the infections.
Although not much is known about this disease, recently one of the genes responsible has been identified as STAT3. It is thought that mutations in the STAT3 gene cause Job syndrome. It is an autosomal dominant disorder meaning just one copy of an altered gene in each cell is ample to cause the disorder. STAT3 is a cell signaling molecule responsible for cell functions such as cell growth and division, cell movement, extracelluar matrix formation (such as bones) and apoptosis (self destruction of redundant/defective cells). Mutations or variations in the genes coding for the STAT3 gene are also responsible for diseases such as Crohn's disease and ulcerative colitis both inflammatory bowel diseases.
Unfortunately as not much is known about the disorder, its treatment and prognosis is not fully known, understood or documented. However known cases have been treated with antibiotics to treat the infections.
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